Research Progress in Chinese Materia Medica Regulating Ferroptosis for the Treatment of Atherosclerosis
10.19879/j.cnki.1005-5304.202312063
- VernacularTitle:中药调控铁死亡治疗动脉粥样硬化研究进展
- Author:
Huiying WANG
1
;
Shaona WANG
;
Liang ZHANG
;
Haixin FU
;
Rui LAN
;
Jitao WU
Author Information
1. 河南中医药大学第一临床医学院,河南郑州 450046
- Publication Type:Journal Article
- Keywords:
Chinese materia medica;
ferroptosis;
atherosclerosis;
review
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2025;32(1):192-196
- CountryChina
- Language:Chinese
-
Abstract:
Atherosclerosis is a chronic vascular disease caused by lipid deposition in the inner wall of blood vessels.Ferroptosis is a non-apoptotic form of cell death characterized by iron dependence and lipid reactive oxygen accumulation.Recent studies have shown that ferroptosis is closely related to the occurrence and development of atherosclerosis.This article explained the correlation between ferroptosis and atherosclerosis from the aspects of foam cell formation,endothelial cell death,vascular smooth muscle proliferation and calcification,and believed that ferroptosis runs through its pathological process.By combing the current research status of the mechanism of Chinese materia medica regulating ferroptosis to treat atherosclerosis,it can be seen that TCM monomers and compounds can reduce endothelial cell dysfunction and inflammatory response,slow down oxidative stress levels,and reduce the accumulation of oxidized lipids under the intima of arterial blood vessels by regulating ferroptosis p53,Nrf2 signaling pathway,amino acid metabolism,lipid metabolism,etc.,so that the blood vessels reach homeostasis,which can provide a reference for the exploration of clinical treatment strategies for atherosclerosis.
