Progress of global tuberculosis vaccines research and development

VernacularTitle:全球结核病疫苗研发进展
Author: Xinyao WANG ¹ ; Meili JIANG ; Yuanjie PANG ; Dianjianyi SUN ; Canqing YU ; Lan WANG ; Jun LYU ; Liming LI
Author Information

1. 北京大学公共卫生学院流行病与卫生统计学系，北京　100191
Publication Type:Journal Article
Keywords: Tuberculosis; Novel tuberculosis vaccine; Progress of research and development; Innovation
From: Chinese Journal of Epidemiology 2025;46(8):1473-1479
CountryChina
Language:Chinese
Abstract: Tuberculosis (TB) is still a major public health issue today. A novel TB vaccine is a key approach to reaching the targets of WHO's End-TB Strategy. In recent years, significant progress has been made in the research and development of TB vaccines both in China and abroad. A breakthrough has been made in both application scenarios and technological routes, and several vaccine candidates have entered phase Ⅲ clinical trials. This review summarizes information from clinical trials involving key TB vaccine candidates under development in China and abroad. It highlights six candidates that are most promising for marketing or inspiring future research and development, analyzes the current difficulties in the research and development of novel TB vaccines, and provides an outlook for the future.