Epidemiological characteristics of marburg virus disease: a systematic review
10.3760/cma.j.cn112338-20250206-00069
- VernacularTitle:马尔堡病毒病流行特征的系统综述
- Author:
Tingting TIAN
1
;
Aqian LI
1
;
Xiaoxia HUANG
1
;
Jiandong LI
1
Author Information
1. 传染病溯源预警与智能决策全国重点实验室，中国疾病预防控制中心病毒病预防控制所，国家卫生健康委员会生物安全重点实验室，国家卫生健康委员会医学病毒和病毒病重点实验室，北京 102206
- Publication Type:Journal Article
- Keywords:
Marburg virus disease;
Epidemiological characteristic;
Marburg virus;
Imported cases
- From:
Chinese Journal of Epidemiology
2025;46(8):1459-1467
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the epidemiological characteristics and natural focus distribution of marburg virus disease (MVD), and provide evidence for the prevention and control of MVD.Methods:A systematic literature retrieval was conducted, and descriptive epidemiological method was used to analyze the temporal, spatial, and population distributions of MVD as well as its natural hosts. The case fatality rate of MVD was evaluated through Meta-analysis, and the phylogenetic analysis of viral genomes was done by using software IQ-TREE 2.3.6.Results:Marburg virus has endemic spread in Africa and can be detected in various animals such as primates and bats. The positive rate is higher in Egyptian fruit bats, and the disease epidemic areas continue to expand. The human infections occur frequently. As of December 20, 2024, a total of 18 MVD outbreaks had been reported worldwide, resulting in 722 reported cases and 548 deaths. Meta- analysis showed a case fatality rate of about 65.19% (95% CI: 48.07%-80.50%). Populations are generally susceptible, with a higher proportion of the cases in miners and medical workers. Marburg virus specific antibody can be detected in populations and animals in some countries and regions where no cases have been reported in Africa, indicating the potential of virus transmission. Conclusion:The transmission capacity of Marburg virus shows no significant changes, but the areas affected by the virus transmission expands, indicating increased risk for MVD outbreak.
