Research progress on the role of cellular senescence in radiation-induced skin injury
10.3760/cma.j.cn114453-20240512-00126
- VernacularTitle:细胞衰老在放射性皮肤损伤中作用的研究进展
- Author:
Wushuang XU
1
;
Xiaozhong ZHOU
;
Lijun WU
Author Information
1. 苏州大学附属第二医院整形美容科，苏州 215000
- Publication Type:Journal Article
- Keywords:
Cell senescence;
DNA damage;
Radiation-induced skin injury;
Senescence associated secretory phenotype;
Inflammatory reaction
- From:
Chinese Journal of Plastic Surgery
2025;41(4):426-433
- CountryChina
- Language:Chinese
-
Abstract:
Radiation-induced skin injury can occur following multiple radiotherapy treatments or nuclear accidents, significantly impacting patients’ quality of life. Radiation-induced skin ulcers often fail to heal and currently lack effective treatment options. Previous studies have demonstrated that cellular senescence is a critical factor contributing to the impaired healing of these ulcers. This article reviews the occurrence and progression of radiation-induced skin damage, the role of cellular senescence in wound healing, potential mechanisms and related biomarkers, and explores the significance of removing senescent cells in alleviating radiation-induced skin damage. It is hoped that this review will provide new insights for the treatment of radiation-induced skin injuries.
