Association of age at menarche, age at menopause, and reproductive lifespan with frailty index in Chinese adult women
10.3760/cma.j.cn112338-20250410-00232
- VernacularTitle:中国成年女性初潮年龄、绝经年龄和生殖寿命与衰弱指数的关联研究
- Author:
Pengyu LI
1
;
Si CHENG
;
Canqing YU
;
Dianjianyi SUN
;
Pei PEI
;
Huaidong DU
;
Junshi CHEN
;
Zhengming CHEN
;
Liming LI
;
Jun LYU
Author Information
1. 北京大学公共卫生学院流行病与卫生统计学系，北京 100191
- Publication Type:Journal Article
- Keywords:
Age at menarche;
Age at menopause;
Reproductive lifespan;
Frailty index;
Trajectory
- From:
Chinese Journal of Epidemiology
2025;46(8):1337-1346
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To identify individuals with accelerated aging under the frailty index (FI) as a proxy indicator of biological age, and to investigate the associations of age at menarche, age at menopause, and reproductive lifespan with frailty status and multi-timepoint FI trajectories among Chinese adult women.Methods:The current study included 302 471 women from the China Kadoorie Biobank 2004-2008 baseline survey data. Their age at menarche and menopause were self-reported, and the duration of reproductive lifespan was calculated by subtracting the two ages. The baseline FI was constructed using 28 baseline variables, including diseases, symptoms, and anthropometric measurements. Frailty status was categorized into three groups: non-frail (FI≤0.10), pre-frail (0.10
