Abnormal cortical complexity of first-episode treatment-naive schizophrenia patients
10.3760/cma.j.issn.1006-7884.2020.01.003
- VernacularTitle:首次发病未治疗精神分裂症患者大脑皮质复杂度改变
- Author:
Wei WEI
1
;
Wei DENG
;
Yi ZHOU
;
Zugui PENG
;
Tao HE
;
Qiuyue LYU
;
Tao LI
Author Information
1. 四川大学华西医院心理卫生中心,成都,610041
- Publication Type:Journal Article
- Keywords:
Schizophrenia;
Magnetic resonance imaging;
Neurodevelopmental hypothesis;
Cortical complexity;
Fractal dimension
- From:
Chinese Journal of Psychiatry
2020;53(1):11-15
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate abnormal cortical complexity in first-episode treatment-naive schizophrenia (FES) and its correlation with clinical symptom.Methods Structural brain images of 77 FES patients and 84 health controls were acquired with Philip 3.0 T MRI.Fractal dimension (FD) was calculated as a proxy of cortical complexity by Computational Anatomy toolbox in SPM12.Partial correlation analysis was conducted to explore relationship between cortical complexity and clinical symptoms.Results FD of left superior frontal lobe (SFL) decreased statistically significantly in FES patients (MNI:x=-5,x=22,z=58;voxel-level P＜0.001,cluster-level family-wise error P＜0.05).FD of left SFL was negatively correlated with PANSS total score (r=-0.357,P=0.028) and negative symptom score of PANSS (r=-0.373,P=0.021) in female patients but not male patients.Conclusions Cortical complexity of left SFL decreased in FES patients and correlated with negative symptoms in female,which suggested that there is early abnormal neural development in schizophrenia.
