Correlation between type 2 diabetes and hepatitis B virus infection
10.3760/cma.j.cn112338-20240909-0056
- VernacularTitle:2型糖尿病与乙型肝炎病毒感染的关联性研究
- Author:
Wu LIU
1
;
Tianshuo ZHAO
;
Liguo YANG
;
Genxia GAO
;
Wenli MIAO
;
Tongxia ZENG
;
Yonglan CHEN
;
Lina ZHANG
;
Xiaoyan CHE
;
Lihong WANG
;
Junhan ZHANG
;
Bingfeng HAN
;
Fuqiang CUI
Author Information
1. 甘肃省靖远县疾病预防控制中心传染病防制科，白银 730699
- Publication Type:Journal Article
- Keywords:
Diabetes;
Hepatitis B;
Observational study;
Prevalence;
Latent infection
- From:
Chinese Journal of Epidemiology
2025;46(5):833-839
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the latent prevalence of hepatitis B and type 2 diabetes and their correlation through an observational study.Methods:This study used a case-control design. The cases with diabetes were recruited through the diabetes management system and village doctors, while the controls without diabetes were screened from volunteers recruited by village health clinics. Capillary blood samples were collected from the study participants for the measurement of real-time blood glucose level, and venous blood samples were taken from them for the detections of HBV serological markers. Firth logistic regression model was used to fit the relationship between HBsAg positive status and diabetes status.Results:The study included 1 218 diabetes patients, 62 patients with impaired fasting glucose and 491 cases without diabetes. In the cases without diagnosis of diabetes, 11.15% had impaired fasting blood glucose and 4.43% had diabetes. Among those who reported no or unknown diagnosis of hepatitis B, 1.73% were positive for HBsAg, while 18.80% were positive for both HBV core antibody and surface antibody, indicating latent infection of hepatitis B virus. In the non-diabetes group, 0.81% reported hepatitis B history, and in the diabetes group, 2.76% reported hepatitis B history. After adjustment, the HBsAg positive rate was higher in the diabetes group ( OR=2.90, 95% CI: 1.21-6.91). Conclusions:Both diabetes and hepatitis B exhibited a high degree of latent prevalence. The HBsAg positive rate was significantly higher in those with diabetes than in those without diabetes, indicating a potential correlation. These findings highlighted the importance of strengthened screening and management of comorbidities.
