Risk factors of recurrence in patients with systemic juvenile idiopathic arthritis
10.3760/cma.j.cn141217-20250423-00122
- VernacularTitle:全身型幼年特发性关节炎复发的影响因素分析
- Author:
Xinran WEN
1
;
Lingling GENG
1
;
Yue PENG
1
;
Li WANG
1
;
Xiaoqing LI
1
Author Information
1. 西安交通大学附属西安市儿童医院风湿免疫科，西安 710003
- Publication Type:Journal Article
- Keywords:
Arthritis, juvenile;
Recurrence;
Risk factor;
Alkaline phosphatase;
Macrophage activation syndrome
- From:
Chinese Journal of Rheumatology
2025;29(7):568-574
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the potential risk factors of recurrence in patients with systemic juvenile idiopathic arthritis (sJIA).Methods:We enrolled patients with sJIA admitted to the Department of Rheumatology and Immunology, Xi′an Children′s Hospital affiliated to Xi′an Jiaotong University from January 2018 to June 2024. Cox proportional hazard models were used to identify clinical features associated with risk of recurrence.Results:This study included a total of 108 children with sJIA, with a median onset age of 79.5 (53.0, 121.5) months. Among them, 52 were male (48.1%) and 56 were female (51.9%). The median time from disease onset to diagnosis was 29.5 (19.0, 57.0) days, and 105 children achieved clinical remission during follow-up. Out of 108 patients with sJIA, 105 patients who achieved clinical remission were enrolled with a median follow-up of 38.0 months. Among them, 28 (26.7%) patients had at least once recurrence. According to the multivariate analysis, macrophage activation syndrome [HR(95% CI)=2.375(1.096, 5.149), P=0.028] and alkaline phosphatase [HR(95% CI)=1.006(1.001, 1.010), P=0.017] were associated with increased risk of recurrence. Conclusion:Our study indicated that recurrence could appear in at least 26.7% patients with sJIA. The high alkaline phosphatase and MAS at initial attack may be independent risk factors of recurrence in patients with systemic Juvenile Idiopathic Arthritis.
