Key mediating factors of ABO glycosyltransferases affecting human diseases: ABH blood group antigens and von Willebrand factor
10.3760/cma.j.cn112338-20240925-00598
- VernacularTitle:ABO糖基转移酶影响人类疾病的关键中介因素：ABH血型抗原与血友病因子
- Author:
Yifan JIANG
1
;
Jingjing LYU
;
Tao JU
;
Xingyu CHEN
;
Guangyu ZHANG
;
Jiang CHANG
;
Chaolong WANG
Author Information
1. 华中科技大学同济医学院公共卫生学院流行病与卫生统计学系，武汉 430030
- Publication Type:Journal Article
- Keywords:
ABO glycosyltransferase;
ABH antigens;
Von Willebrand factor;
ABO blood type
- From:
Chinese Journal of Epidemiology
2025;46(5):880-887
- CountryChina
- Language:Chinese
-
Abstract:
Epidemiology research has found that ABO blood group and the gene coding ABO glycosyltransferases are associated with many human diseases. The activity of ABO glycosyltransferases varies with different blood types, mediating different glycosylation modifications. The variation in glycosylation level might be the risk factor of specific disease. Based on the literature retrieval and analysis, glycosylation levels regulated by ABO glycosyltransferases mainly affect the ABH blood group antigens and von Willebrand factor (vWF). By modulating key glycosylation components, ABO glycosyltransferases partly determine the activity or expression levels of the ABH antigens and vWF, thereby affecting the development and progression of diseases. Exploring the pathogenic mechanisms of ABO glycosyltransferases can improve the understanding of the molecular pathology of related diseases and provide reference for clinical research and application.
