Progress of matrix Gla protein in malignant tumors
10.3760/cma.j.cn115355-20241013-00470
- VernacularTitle:基质Gla蛋白在恶性肿瘤中的研究进展
- Author:
Na ZHOU
1
;
Yanling HE
1
;
Tong CHENG
1
;
Hao CHEN
1
Author Information
1. 徐州医科大学附属连云港医院，连云港 222000
- Publication Type:Journal Article
- Keywords:
Matrix Gla protein;
Neoplasm;
Vitamin K;
Tumor markers, biological
- From:
Cancer Research and Clinic
2025;37(9):709-712
- CountryChina
- Language:Chinese
-
Abstract:
Matrix Gla protein (MGP) is a vitamin K-dependent protein secreted by chondrocytes and vascular smooth muscle cells. It is mainly distributed in cartilage, bone marrow, and arterial walls, and participates in osteogenic differentiation and vascular calcification processes in vascular smooth muscle. Previous studies have suggested that MGP only has inhibitory effects on physiological and ectopic calcification. A new study has found that MGP is highly expressed in various tumor tissues, but the relationship between its expression level and the malignant biological behavior of tumors is not completely consistent in different tumors. The differential expression of MGP may be a result of tumor heterogeneity. This article reviews the research progress of MGP in multi-system malignant tumors, in order to provide new ideas for the diagnosis and treatment of clinical malignant tumors.
