Predictive value of combined detection of serum uric acid and carcinoembryonic antigen for lymph node metastasis in gastric cancer
10.3760/cma.j.cn115355-20240920-00442
- VernacularTitle:血清尿酸与癌胚抗原联合检测对胃癌淋巴结转移的预测价值
- Author:
Jianyun JIN
1
;
Jie YAN
Author Information
1. 晋城市人民医院普通外科一病区，晋城 048000
- Publication Type:Journal Article
- Keywords:
Stomach neoplasms;
Uric acid;
Carcinoembryonic antigen;
Lymph node metastasis
- From:
Cancer Research and Clinic
2025;37(9):690-694
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the predictive value of combined detection of serum uric acid and carcinoembryonic antigen (CEA) for lymph node metastasis in gastric cancer.Methods:A retrospective case series study was conducted. A total of 185 patients who underwent radical gastrectomy for gastric cancer at Jincheng People's Hospital from December 2020 to December 2022 were selected. Based on postoperative pathology results, they were divided into lymph node non-metastasis group (group A, 75 cases) and lymph node metastasis group (group B, 110 cases). Logistic regression analysis was performed to identify the risk factors, and receiver operating characteristic (ROC) curve was used to evaluate the diagnostic efficacy of uric acid or CEA detection alone and in combination for predicting lymph node metastasis in gastric cancer.Results:There were 60 males and 15 females in group A, with an age of (62±10) years; there were 91 males and 19 females in group B, with an age of (64±8) years. There was no statistically significant difference in age, gender, tumor differentiation degree, creatinine, urea, urea-to-creatinine ratio, and serum albumin (ALB) between the two groups of patients (all P > 0.05). However, there were statistically significant differences in tumor diameter, uric acid and CEA (all P < 0.05). The tumor diameter [ M ( Q1, Q3)] in group B was longer than that in group A [5.5 (4.0, 7.0) cm vs. 3.5 (2.5, 6.0) cm], and the levels of uric acid [(284±80) μmol/L vs. (245±62) μmol/L] and CEA [2.60 (1.23, 6.49) μg/L vs. 1.69 (1.11, 2.65) μg/L] were higher than those in group A, the differences were statistically significant (all P < 0.05). The results of multivariate analysis showed that tumor diameter ( OR = 1.264, 95% CI: 1.905-1.459, P = 0.001), uric acid ( OR = 1.007, 95% CI: 1.002-1.012, P = 0.008) and CEA ( OR = 1.215, 95% CI: 1.043-1.416, P = 0.013) were independent factors affecting lymph node metastasis in gastric cancer. The area under the ROC curve (AUC) of uric acid detection alone for predicting lymph node metastasis in gastric cancer was 0.644 (the sensitivity was 39.1%, the specificity was 90.7%), CEA detection alone was 0.652 (the sensitivity was 59.1%, the specificity was 70.7%), and the combined detection of the two was 0.722 (the sensitivity was 68.2%, the specificity was 70.7%). Conclusions:Uric acid, CEA and tumor diameter are independent influencing factors for lymph node metastasis in gastric cancer. The combined detection of uric acid and CEA can significantly improve the predictive efficiency of lymph node metastasis in gastric cancer.
