Research progress on adverse prognosis after recanalization therapy for acute ischemic stroke

VernacularTitle:急性缺血性脑卒中再通治疗后发生不良预后的研究进展
Author: Rennv WANG ¹ ; Yuexin LU ; Ming WANG ; Shu WAN
Author Information

1. 浙江中医药大学研究生院，杭州　310053
Publication Type:Journal Article
Keywords: Ischemic stroke; Futile recanalization; Early neurological deterioration; Haemorrhagic transformation
From: Journal of Chinese Physician 2025;27(7):1106-1110
CountryChina
Language:Chinese
Abstract: Acute ischemic stroke (AIS) is a comprehensive syndrome characterized by neurological dysfunction, resulting from cerebral tissue ischemia and hypoxia due to impaired blood supply, which further leads to tissue softening or even necrosis. Restoring blood flow through recanalization of the occluded vessel is crucial for AIS treatment. Although more and more patients benefit from intravenous thrombolysis or endovascular therapy, some still have poor prognosis after vessel recanalization. Most studies indicate that ineffective recanalization, early neurological deterioration, and hemorrhagic transformation are the three main causes of adverse prognosis after recanalization therapy for AIS. This article systematically reviews the epidemiological characteristics, pathogenesis, and risk factors of the above three aspects based on previous studies, aiming to provide guidance for the diagnosis and treatment of adverse prognosis in AIS patients after recanalization therapy.