Research progress on the relationship between cerebral lymphatic system and post-stroke cognitive impairment
10.3760/cma.j.cn431274-20240614-00946
- VernacularTitle:脑类淋巴系统与卒中后认知障碍关系的研究进展
- Author:
Qiuju LI
1
;
Yuhui WANG
1
Author Information
1. 上海市浦东新区浦南医院神经内科，上海 200125
- Publication Type:Journal Article
- Keywords:
Brain glymphatic system;
Post-stroke cognitive impairment;
Aquaporin 4;
Amyloid-beta
- From:
Journal of Chinese Physician
2025;27(7):1111-1115
- CountryChina
- Language:Chinese
-
Abstract:
Post-stroke cognitive impairment (PSCI) is one of the most common complications of stroke and an important reason for the poor prognosis of patients with motor and language dysfunction after stroke. However, its exact pathogenesis has not been fully clarified. An in-depth understanding of the pathophysiological process of PSCI is crucial for establishing effective prevention and treatment strategies. The cerebral lymphoid system is a key waste clearance pathway discovered in the central nervous system in recent years, and its potential role in neurodegenerative diseases has received extensive attention. More and more studies suggest that the cerebral lymphatic system may be closely related to the occurrence and development of PSCI. This article aims to explore the basic structure and function of the cerebral lymphatic system, as well as its mechanism of action in PSCI. We systematically reviewed the research progress on the potential connection between the cerebral lymphatic system and PSCI. Furthermore, this article also summarizes the potential applications of the cerebral lymphatic system in the treatment of PSCI and presents prospects for future research directions.
