Ticagrelor-induced respiratory depression:two cases report

VernacularTitle:替格瑞洛致呼吸抑制2例
Author: Xian ZHAO ¹ ; Pei ZHANG ; Yulai WANG ; Zhen LU ; Haiyan SUN
Author Information

1. 435000,湖北理工学院附属鄂东医疗集团黄石市中心医院药学部
Publication Type:Journal Article
Keywords: Purinergic P2Y12 receptor antagonists; Apnea; adenosine; Ticagrelor
From: Adverse Drug Reactions Journal 2018;20(6):442-443
CountryChina
Language:Chinese
Abstract: Two male patients (patient 1,75 years old;patient 2,63 years old )underwent percutaneous coronary intervention for acute coronary syndrome. After operation,they were given ticagrelor 90 mg twice daily orally to prevent stent thrombosis. Two patients developed chest tightness and respiratory depression both about 4 hours after their first dose,with decreased respiratory rates of 9-12 and 9-13 breaths/min,respectively. In addition,patient 1 developed sleep apnea on the night after the operation. Ticagrelor was stopped and replaced by clopidogrel on the third and second day,respectively in the 2 patients. After 12 and 10 hours of ticagrelor withdrawal,the respiratory depression disappeared and did not recur at 3 and 6 days of follow-up.