Impact of osteoporosis on fracture healing and strategies for pharmacological intervention
10.3760/cma.j.cn121113-20241011-00560
- VernacularTitle:骨质疏松对骨折愈合的影响及药物干预策略
- Author:
Yike WANG
1
;
Youjia XU
Author Information
1. 苏州大学附属第二医院骨科，骨质疏松临床中心，苏州 215000
- Publication Type:Journal Article
- Keywords:
Osteoporotic fractures;
Healing characteristics
- From:
Chinese Journal of Orthopaedics
2025;45(2):126-132
- CountryChina
- Language:Chinese
-
Abstract:
Osteoporotic fractures are characterized by reduced bone mass and microstructural abnormalities, leading to differences in the healing process compared to traumatic fractures. The fracture healing process is generally divided into the inflammatory phase, the repair phase and the remodeling phase. In patients with osteoporotic fractures, due to factors such as decreased bone density, reduced bone quality and aging, there are partial alterations in inflammatory cells and osteoimmunity associated with those three healing phases, ultimately affecting fracture healing. This article focuses on the differences in fracture healing between non-osteoporotic fractures and osteoporotic fractures, reviewing relevant research literature and consensus. It analyzes and discusses changes in bone marrow mesenchymal stem cells and bone metabolism during osteoporosis, the effects of inflammatory aging, underlying diseases, and anti-osteoporosis medications on fracture healing, as well as the changes observed after pharmacological intervention. The aim is to emphasize personalized treatment approaches that account for individual and bone-specific factors in managing osteoporotic fractures, striving to promote better fracture healing outcomes and improving patients' quality of life.
