Dermatitis exfoliativa due to azithromycin with etimicin sequentially
10.3760/cma.j.issn.1008-5734.2018.06.013
- VernacularTitle:阿奇霉素序贯依替米星引起剥脱性皮炎
- Author:
Xiaolian QI
1
Author Information
1. 首都医科大学宣武医院药学部/北京市老年病医疗研究中心/国家老年病临床医学研究中心,北京,100053
- Publication Type:Journal Article
- Keywords:
Dermatitis,exfoliative;
Macrolides;
Aminoglycosides;
Azithromycin;
Etimicin
- From:
Adverse Drug Reactions Journal
2018;20(6):450-451
- CountryChina
- Language:Chinese
-
Abstract:
A 35-year-old female patient with acute cerebral infarction received an IV infusion of azithromycin 0.5 g once daily for combination with pneumonia. About 10 minutes after completing the first infusion,scattered red miliary rash with itching appeared on the patient′s upper limbs,chest,and back. Drug eruption was considered,and dexamethasone 10 mg by an IV injection and loratadine tablets 10 mg by mouth once daily were given. On day 2 of admission,an IV infusion of etimicin sulfate 0.3 g,added into 0.9% sodium chloride injection 250 ml,was given once daily as anti-infective treatment. On day 7,with the disappearance of rash and itching,dexamethasone was replaced by prednisone tablets 30 mg orally once daily,and finally prednisone but not loratadine tablets were discontinued on day 14 through gradual reduction dose of 10 mg every 3 days. On day 15,the patient developed systemic diffuse erythema and facial and limb edema,and then an IV injection of dexamethasone 10 mg once daily was given again. On day 17,with the disappearance of erythema and reduction of edema,desquamation occurred on the patient′s face,body and limbs,which was diagnosed as exfoliative dermatitis,and topical 0.1% halcinonide solution mixed with Yumeijing moisturizer was given externally thrice daily. On day 19,the patient′s skin desquamation improved and edema subsided,and then the dose of dexamethasone was reduced to 5 mg once daily. On day 22,as the desquamation became slighter,dexamethasone was replaced by prednisone tablets 30 mg orally once daily,and the dose of prednisone was gradually reduced by 5 mg every 5 days. On day 26,all symptoms on the patient′s skin disappeared. The rash did not recur at 1 month of follow-up.
