Association between body mass index and calcaneus bone mineral density in adults in a cross-sectional study in Tongxiang, Zhejiang Province
10.3760/cma.j.cn112338-20240805-00477
- VernacularTitle:浙江省桐乡市成年人体质指数和跟骨骨密度关联的研究
- Author:
Hao WANG
1
;
Kaixu XIE
;
Lingli CHEN
;
Hao XU
;
Zhengjie SHEN
;
Jun LYU
;
Canqing YU
;
Dianjianyi SUN
;
Pei PEI
;
Jieming ZHONG
;
Min YU
Author Information
1. 浙江省疾病预防控制中心慢性非传染性疾病预防控制所，杭州 310051
- Publication Type:Journal Article
- Keywords:
Bone mineral density;
Body mass index;
Stiffness index;
Cross-sectional study
- From:
Chinese Journal of Epidemiology
2025;46(3):448-454
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the association between body mass index (BMI) and bone mineral density of calcaneus in adults.Methods:Data of the second resurvey of China Kadoorie Biobank study from Tongxiang of Zhejiang Province were used. A total of 2 896 participants aged 44-84 years were included in the final analysis. Overweight was defined as 23.0 kg/m 2≤BMI<25.0 kg/m 2, and obesity was defined as BMI ≥25.0 kg/m 2 based on the criteria recommended by WHO/West Pacific Region. Multiple linear regression model was used to evaluate the association between BMI and calcaneus bone mineral density. Restricted cubic splines were used to investigate the dose-response relationship between BMI and calcaneus bone mineral density. Results:The calcaneus bone mineral density in the study subjects were as follow ( x± SE): the broadband ultrasound attenuation was (109.4±12.1) dB/MHz, the speed of ultrasound was (1 545.9±33.8) m/s, and the stiffness index was 85.7±15.8. After adjusting for socio-demographic factors, lifestyle, waist circumference, diabetes and hypertension prevalence, BMI was positively associated with calcaneus stiffness index in non-overweight and non-obese adults, with β of 2.30 (95% CI: 1.11-3.49) for men ( P<0.001) and 1.08 (95% CI: 0.38-1.78) for women ( P=0.003), respectively. In addition, BMI was positively associated with calcaneus stiffness index in overweight and obese women ( β=0.90, 95% CI: 0.38-1.42) ( P<0.001), and null association was found in overweight and obese men ( β=0.06, 95% CI: -0.92-1.04) ( P=0.900). Restricted cubic spline model showed a nonlinear dose-response relationship between BMI and calcaneus stiffness index. Conclusion:Non-linear association was found between BMI with calcaneus bone mineral density in adults.
