Impact of statin adherence on the prognosis of patients with myocardial infarction and cerebral infarction
10.3760/cma.j.issn.1008-5734.2018.05.010
- VernacularTitle:他汀类药物依从性对心肌梗死及脑梗死患者预后的影响
- Author:
Xuewei FU
1
;
Xin MA
;
Yungao WAN
Author Information
1. 首都医科大学宣武医院心脏科,北京,100053
- Publication Type:Journal Article
- Keywords:
Hydroxymethylglutaryl-CoA reductase inhibitors;
Medication adherence;
Cerebral infarction;
Myocardial infarction;
Prognosis
- From:
Adverse Drug Reactions Journal
2018;20(5):370-375
- CountryChina
- Language:Chinese
-
Abstract:
As the secondary preventive drug for cardiovascular and cerebrovascular diseases,statins can significantly improve the prognosis of patients with myocardial infarction and cerebral infarction.However,the investigations on the application of statins showed that statin withdrawal and dose reduction are very common in patients with acute myocardial infarction and cerebral infarction.After 6 months of treatment,patients with good adherence were less than 60％.With the prolongation of treatment time,the proportion of patients with poor adherence or discontinued treatment gradually increased.The decline of adherence to statin therapy was related to many factors,such as patients' concern about drug safety,insufficient communication between doctors and patients,excessive combination of drugs,and economic status and educational levels of patients.Adherence to statin therapy could affect markedly the prognosis of atherosclerotic cardiovascular disease and poor statin adherence could increase the incidence of major adverse cardiovascular events.It is necessary to improve the physician'awareness of importance of statin therapy,strengthen the education of medication adherence,rationally select treatment drugs,monitor adverse drug reactions,and enhance patients' adherence to statin therapy.
