Serious disulfide like reaction caused by combined use of cefoperazone sodium and tazobactam sodium and hydrocortisone injection
10.3760/cma.j.issn.1008-5734.2018.05.017
- VernacularTitle:头孢哌酮钠他唑巴坦钠与氢化可的松注射液联用致严重双硫仑样反应
- Author:
Qinglin YE
1
;
Zizhao WANG
;
Ning ZHANG
;
Xianyu LI
;
Xiaomei SHI
;
Jianhua SUN
Author Information
1. 解放军第三七一中心医院药械科, 河南新乡,453000
- Publication Type:Journal Article
- Keywords:
Cefoperazone;
Hydrocortisone;
Disulfiram;
Drug interactions
- From:
Adverse Drug Reactions Journal
2018;20(5):388-390
- CountryChina
- Language:Chinese
-
Abstract:
A 77-year-old female patient underwent a laparoscopic left radical nephrectomy for renal malignant neoplasm.She received an IV infusion of cefoperazone sodium and tazobactam sodium 2 g about 30 minutes before surgery and an IV infusion of hydrocortisone injection 400 mg during the operation.On the 2nd day after surgery,intravenous infusion of cefoperazone sodium and tazobactam sodium (2 g twice daily) and hydrocortisone injection (200 mg once daily) were given sequentially.On the 3rd day after operation,about 30 min after completion of the IV infusion of hydrocortisone injection,the patient's blood pressure dropped suddenly to 84/48 mmHg,her heart rate was 150 beats per minute,and clouding of consciousness,lethargy,generalized flush and sweating appeared.Adrenal crisis was considered.Dexamethasone,hydrocortisone,dopamine,epinephrine,and etc.were successively given to rescue her.About 30 minutes later,the patient's symptoms improved slightly and then the patient was immediately transferred to ICU.In ICU,cefoperazone sodium and tazobactam sodium was continued according to the original scheme,hydrocortisone injection was changed to 150 mg twice daily,and the 2 groups of drugs were infused at 2-hour intervals.At the same time,dopamine 360 mg dissolved in 50 ml of 0.9％ sodium chloride injection was administered intravenously via an infusion pump.The patient's condition improved.On the 7th day after operation,the 2 groups of drugs were intravenously infused sequentially again and the similar symptoms appeared again.The pharmacist considered that the disulfiram-like reactions was caused by the combined use of cefoperazone sodium and tazobactam sodium and hydrocortisone injection and suggested that the two drugs should be discontinued.After the drugs withdrawal,no similar symptoms recurred.
