Leukoencephalopathy due to 5-fluorouracil in a patient with invasive mole
10.3760/cma.j.issn.1008-5734.2018.05.021
- VernacularTitle:5-氟尿嘧啶致侵蚀性葡萄胎患者脑白质损伤
- Author:
Jing NING
1
;
Zhentao YANG
1
;
Fuquan LIU
1
;
Li'an LI
1
Author Information
1. 解放军总医院海南分院妇产科, 海南省三亚市,572013
- Publication Type:Journal Article
- Keywords:
Hydatidiform mole,invasive;
Fluorouracil;
Leukoencephalopathies
- From:
Adverse Drug Reactions Journal
2018;20(5):396-398
- CountryChina
- Language:Chinese
-
Abstract:
A 36 year-old female patient with stage Ⅱ invasive mole (low-risk type) received single drug chemotherapy with 5-fluorouracil (5-Fu).The 5-Fu (30 mg/kg) was given by an intravenous infusion from the first day to the eighth day in each 22-day chemotherapy cycle.The patient developed dysarthria and dysphagia during the 5-Fu treatment on day 6 in the third cycle.The result of head magnetic resonance imaging (MRI) showed extensive white matter injury.5-Fu was immediately discontinued and nutritional supportive treatments to brain cells were given.Five hours later,the above symptoms disappeared.Twentyfour hours later,the above symptoms recurred and above-mentioned supportive treatments were given again.Three hours after the treatment,the above symptoms disappeared again.Then the chemotherapy regimen was changed to be an IV infusion of actinomycin D (0.4 mg/d) from the first day to the fifth day in each 19-day cycle.During the treatment,the patient's vital signs were stable and her pronunciation and ingurgitation functions were normal.
