Osteonecrosis as a serious adverse reaction of glucocorticoids
10.3760/j.issn.1008-5734.1999.01.011
- VernacularTitle:糖皮质激素引致的严重不良反应——骨坏死
- Author:
Zili LI
1
;
Shushan SHI
1
;
Jinwei JIANG
1
;
Renrun WANG
1
;
Fang LI
1
Author Information
1. 北京军区总医院,北京,100700
- Publication Type:Journal Article
- Keywords:
adverse drug reactions;
glucocorticoids;
osteonecrosis
- From:
Adverse Drug Reactions Journal
1999;1(1):33-35
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyse osteonecrosis induced by glucocorticoids in the clinical practice,and provide basis for early prevention,diagnosis and treatment.Methods:128 cases of osteonecrosiss were induced by glucocorticoidstreatment during the 10 years between 1986 and 1995,and the aspects of age,sex,course of diseases,primary diseases,dose of glucocorticoids,and early clinical manifestation were analysed.Results:The incidence of osteonecrosis was lower in doses normlly than in doses abnormally,and the incidence was higher in long treatment course than in short treatment course.Conclusion:Rational use of glucocorticoids and early prevention can reduce the incidence of osteonecrosis.
