Effects of escitalopram on coagulation function in depression patients
10.3760/cma.j.issn.1008-5734.2018.02.007
- VernacularTitle:艾司西酞普兰对抑郁症患者凝血功能的影响
- Author:
Zhongxia SHEN
1
;
Xiaomei ZHANG
;
Min CAI
;
Song GEN
;
Zhen ZHANG
;
Shengliang YANG
;
Xinhua SHEN
Author Information
1. 湖州市第三人民医院心身障碍科,浙江湖州,313000
- Publication Type:Journal Article
- Keywords:
Citalopram;
Depression;
Blood coagulation
- From:
Adverse Drug Reactions Journal
2018;20(2):117-121
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effects of escitalopram on coagulation function in depression patients. Methods This was a self-controlled prospective study. The subjects were depression patients (Hamilton Depression Scale(HAMD)score>17)who presented to or hospitalized in the Department of Psychosomatic Disorders in the Third People′s Hospital of Huzhou City from June 1,2016 to June 1,2017. The patients in accordance with inclusion criteria were treated with escitalopram(initial dose was 5 mg/d and increased to 10-20 mg/d within 2 weeks). HAMD rating scale were performed,prothrombin time (PT),activated partial thromboplastin time(APTT),thrombin time(TT)and fibrinogen(FIB)were detected before treatment and 4 weeks after treatment. Response was defined as a 50% reduction in HAMD score. Results A total of 95 patients finished the 4 weeks treatment with escitalopram. Of them,38 patients were male with ages from 21 to 64 years and mean age of(39 ± 12)years,with illness duration from 14 to 60 months and mean illness duration of(32 ± 12)years;57 cases were female with ages from 20 to 64 years and mean age of(38 ± 13)years,with illness duration from 12 to 54 and mean illness duration of (28 ± 12)years. HAMD score were(21.8 ± 3.4)and(9.1 ± 3.3)before and after 4 weeks treatment, respectively(t=26.125,P<0.001). The levels of PT,APTT,and TT in patients after 4 weeks treatment were significantly higher than those before treatment[(11.14 ±1.22)s vs.(11.66 ±1.41)s,(29.45 ± 5.24)s vs.(31.28 ± 5.64)s,(20.32 ± 2.08)s vs.(21.15 ± 2.21)s,respectively,all P<0.05]. However, the FIB level after 4 weeks treatment was significantly decreased than that before treatment[(1.92 ± 0.28) g/L vs.(2.01 ± 0.34)g/L,P <0.05]. There were no significant differences among the indexes of coagulation function among the patients with different sex(P>0.05). After treatment,the increased values of PT and TT levels and the decreased value of FIB level in female patients were significantly higher than those in male patients(all P<0.05). After treatment,there were no significant differences in the increased value of PT,TT and APTT and the decreased value of FIB between the response group(80 cases)and the non-response group(15 cases)(all P >0. 05). One 24-year-old female patient presented with upper gastrointestinal bleeding after more than 1 month of escitalopram treatment at a dose of 15 mg/d. Conclusion Escitalopram has an influence on coagulation function in depression patients,especially in female patients,which may increase the risk of bleeding.
