Serious liver damage caused by butylphthalide soft capsule
10.3760/cma.j.issn.1008-5734.2018.01.016
- VernacularTitle:丁苯肽软胶囊致严重肝损伤
- Author:
Yingqin SHI
1
;
Yao LI
1
Author Information
1. 河北省人民医院药学部,石家庄,050051
- Publication Type:Journal Article
- Keywords:
Drug-induced liver injury;
Butylphthalide soft capsules
- From:
Adverse Drug Reactions Journal
2018;20(1):62-63
- CountryChina
- Language:Chinese
-
Abstract:
A 78-year-old female patient with acute cerebral infarction received butylphtha-lide soft capsules 0.2 mg thrice daily. One week later,she experienced fatigue and anorexia. Two weeks later,she presented with yellowish skin and sclera. Laboratory tests revealed the following levels:aminotransferase (ALT)1 574 U/L,aspartate aminotransferase(AST)1 135 U/L,direct bilirubin(DBil)58.8 μmol/L, indirect bilirubin(IBil)62. 0 μmol/L. Liver damage was diagnosed and considered to be related to butylphthalide soft capsules,and then the medication was discontinued. The patient was given IV infusions of reduced glutathione 1.8 mg,Shuganning injection(舒肝宁注射液)10 ml,polyene phosphorylcholine 232.5 mg and magnesium isoglycyrrhizinate 150 mg once daily. On day 4 after symptomatic treatment,she had an ALT level of 840 U/L,an AST level of 640 U/L,a DBil level of 50.1 μmol/L,an IBil level of 57.1 μmol/L. On day 17,the yellowish skin and sclera significantly improved,the diet returned to normal and physical strength recovered,the results of reexaminination showed ALT 64 U/L,AST 41 U/L,DBil 13.9 μmol/L,IBil 18.6 μmol/L.
