Acute left heart failure induced by apatinib
10.3760/cma.j.issn.1008-5734.2018.01.017
- VernacularTitle:阿帕替尼致急性左心衰竭
- Author:
Ting DAI
1
;
Wenlan PAN
1
;
Junping GUO
1
Author Information
1. 214200,江苏省宜兴市人民医院药学部
- Publication Type:Journal Article
- Keywords:
Neovascularization Inhibitors;
Antineoplastic Agents;
Heart Failure
- From:
Adverse Drug Reactions Journal
2018;20(1):63-64
- CountryChina
- Language:Chinese
-
Abstract:
A 52-year-old women with multiple metastasis of cervical cancer started to receive the targeted therapy with apatinib(250 mg daily). Five months later,the patient developed chest tightness and shortness of breath. The symptoms were not relieved after oxygen and intravenous methylprednisolone 40 mg were given. Ninety minutes later,the patient developed dyspnea,cough,pinky foam sputum,bilateral lower pulmonary rales,and elevated myocardial enzymes. An intravenous bolus of Cedilanid 0.3 mg and furose-mide 20 mg were given,and her symptoms were relieved. Apatinib was discontinued,and she was treated with glyceryl trinitrate 10 mg,aspirin 0.1g daily,clopidogrel 75 mg daily,atorvastatin calcium 20 mg daily, and metoprolol 12.5 mg twice daily. The patient's symptoms were relieved at day 2 after treatment. The myocardial enzymes declined gradually,and it returned to normal 12 days later. Two months after apatinib withdrawal,the symptoms of acute left heart failure did not reccur.
