Thrombocytopenia crisis and purpura due to antitubercular agents
10.3760/cma.j.issn.1008-5734.2018.01.014
- VernacularTitle:抗结核药引起血小板减少危象并紫癜
- Author:
Yuanyuan LIU
1
;
Rugui LI
1
;
Bo HU
1
;
Jinke LI
1
;
Huabing TAN
1
Author Information
1. 湖北医药学院附属人民医院感染性疾病科, 湖北省十堰,442000
- Publication Type:Journal Article
- Keywords:
Antitubercular Agents;
Purpura,thrombocytopenic
- From:
Adverse Drug Reactions Journal
2018;20(1):58-59
- CountryChina
- Language:Chinese
-
Abstract:
A 53-year-old male patient who had a history of pulmonary tuberculosis with fever, hyperhidrosis with slight cough,in other hospital diagnosed as pulmonary tuberculosis,received quadruple anti tuberculosis therapy(isoniazid,rifampicin,pyrazinamide and ethambutol). On the 11th day of therapy,patients developed nasal bleeding and lower extremity ecchymosis petechiae,rapidly expanding to the whole body. On the 13th day,the patient was sent to our hospital,the blood routine examination showed his blood platelet count(PLT)was 1×109/L,the antituberculous drugs were discontinued,and the treatment of raising platelets,anti allergy,hemostasis and anti infection was given. On the 4th day of treatment,the patient's temperature returned to normal,the nasal bleeding stopped,and PLT was 18×109/L. On the 7th day,his body ecchymosis subside,and PLT was 92×109/L. On the 16th day,his PLT was 151×109/L, and multi-slice spiral CT examination showed right lower lung lesion was absorbed.
