Role of stem cells in scalp aging and related therapeutic strategies
- VernacularTitle:干细胞在头皮衰老中的作用及相关治疗策略
- Author:
Weiyun DING
1
;
Jinran LIN
;
Qingmei LIU
;
Yue ZHANG
;
Kai YANG
;
Chunya NI
;
Wenyu WU
Author Information
- Publication Type:Journal Article
- Keywords: Hair follicle; Aging; Alopecia; Scalp; Hair regeneration; Epigenetics; Apoptosis; Exosomes
- From: Chinese Journal of Dermatology 2025;58(7):671-675
- CountryChina
- Language:Chinese
- Abstract: Changes in hair follicle stem cells (HFSCs) can affect scalp aging and hair growth. With increasing age, HFSCs exhibit a decrease in quiescence maintenance and self-renewal capacity, as well as differentiation potential, leading to shortened hair growth cycles and even hair loss. This review summarizes recent research advances in the multifactorial interactions underlying hair loss, including the regulatory mechanisms of HFSC quiescence, the impact of aging on HFSC function, and aging of the stem cell microenvironment. Additionally, this review discusses the relationship between stem cells and hair shafts, and the mechanisms of action of stem cells in scalp aging, including alterations in signaling pathways, chromatin remodeling, and epigenetic regulation, etc. Furthermore, stem cell-based therapeutic strategies are summarized, such as the use of stem cells or their secreting exosomes, modulation of the stem cell microenvironment, and pharmacological interventions.
