Critically dysregulated signaling pathways and clinical utility of the pathway biomarkers in lymphoid malignancies
- Author:
Sun RUI-FANG
1
;
Yu QIAN-QIAN
;
Ken H. YOUNG
Author Information
1. Tumor Biobank, Department of Pathology, Shanxi Cancer Hospital, Taiyuan, Shanxi 030013, China
- Publication Type:Journal Article
- Keywords:
Lymphoma;
Signaling pathway;
Biomarker;
Therapeutic target
- From:
Chronic Diseases and Translational Medicine
2018;4(1):29-44
- CountryChina
- Language:English
-
Abstract:
Accumulating evidence confirmed that many dysregulated signaling pathways and aberrant genetic alterations contribute to the oncogenesis and heterogeneity of lymphoid malignancies. Therapeutically targeting dysregulating signaling pathways and their hidden oncogenic biomarkers are becoming available, but did not show desired therapeutic effect in current clinical practice. It is meaningful to further understand the underlying mechanisms of the dysregulated signaling pathways and to address the potential utility of pathway-related biomarkers. To precisely identify the dysregulation of signaling pathways and the "driver" oncogenic biomarkers, as well as to develop reliable and reproducible risk-stratification based on biomarkers will be challenging. Never-theless, pathway-based targeted therapy will raise the hope to improve the outcomes of the patients with lymphoid malignancies, especially with aggressive types, and the efficient utility of pathway-related biomarkers in diagnosis, prognosis, prediction of lymphoid malignancies may also be able to power precision medicine.
