Research progress on the role of microRNA in Alzheimer's disease
10.3969/j.issn.1004-1648.2024.06.019
- VernacularTitle:微小RNA在Alzheimer's病中作用的研究进展
- Author:
Jin ZHONG
1
;
Xinran XU
1
;
Ting WU
1
Author Information
1. 210029 南京医科大学第一附属医院神经内科
- Publication Type:Journal Article
- Keywords:
Alzheimer's disease;
microRNA;
pathogenesis;
biomarkers;
therapeutic target
- From:
Journal of Clinical Neurology
2024;37(6):459-463
- CountryChina
- Language:Chinese
-
Abstract:
Alzheimer's disease(AD)is a common neurodegenerative disease characterized by the accumulation of β-amyloid plaques and neurofibrillary tangles in the brain.MicroRNAs(miRNAs)are a class of small molecule non-coding RNAs that are maturely processed from precursor miRNAs by the action of enzymes such as Dicer.miRNAs play an important role in a variety of biological processes by binding to target mRNAs to regulate gene expression.Studies found that a variety of miRNAs were abnormally expressed in the brain tissues and peripheral body fluids of AD patients,and these miRNAs were involved in AD-related β-amyloid metabolism,synaptic function,neuronal apoptosis,and neuroinflammation.This article reviews the role of miRNA in the pathology of AD,and provides a theoretical basis for its application in the diagnosis and treatment of AD.
