Clinical analysis of liver injury associated with edaravone in patients with acute ischemic stroke
10.3760/cma.j.issn.1008-5734.2018.03.002
- VernacularTitle:急性缺血性脑卒中患者依达拉奉治疗相关肝损伤临床分析
- Author:
Lipo SONG
1
;
Chunmei WANG
;
Yanqi CHU
;
Xunming JI
;
Jiangang DUAN
;
Libing WEI
;
Yachan NING
;
Ying HUANG
;
Jian ZHANG
Author Information
1. 首都医科大学宣武医院血管外科重症监护病房, 北京,100053
- Publication Type:Journal Article
- Keywords:
Stroke;
Free radical scavengers;
Drug-induced liver injury
- From:
Adverse Drug Reactions Journal
2018;20(3):164-168
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the clinical characteristics of liver injury related to edaravone in treating patients with acute ischemic stroke (AIS). Methods Among the AIS patients treated with edaravone in Vascular Surgery ICU of Xuanwu Hospital Capital Medical University from January 2014 to October 2017,9 patients were diagnosed as having liver injury associated with edaravone by active monitoring. The total number of patients treated with edaravone at the same period in Vascular Surgery ICU were obtained from the hospital information system and the incidence of liver injury associated with edaravone was calculated. The clinical data of the 9 patients were collected and analyzed retrospectively. Results The incidence of liver injury associated with edaravone was 8.7% (9/103 ). The 9 patients included 6 males and 3 females. The age of the patients was 52-83 years and their average age was (65 ± 6)years. The time for the occurrence of liver injury was 3-9 days and the average time was (6 ± 2)days. The main manifestations of liver injury were increase of alanine aminotransferase (9 cases),aspartic aminotransferase (7 cases),alkaline phosphatase (4 cases),total bilirubin (2 cases),and accompanied by rash in 1 case. Using RUCAM scale,7 patients were classified as ＂highly probable＂ and 2 patients were classified as＂probable＂. Using ＂Grade of DILI severity＂＂ standard,all the 9 patients were diagnosed as ＂mild liver injury＂. After 4-13 days of edaravone withdrawal,8 patients had normal liver function and 1 case improved. Conclusions Edaravone might cause liver injury,mainly manifesting liver dysfunction. The degree of liver injury was mild,and the prognosis was good after timely intervention.
