Extrapyramidal symptoms caused by aripiprazole
10.3760/cma.j.issn.1008-5734.2018.03.017
- VernacularTitle:阿立哌唑致锥体外系症状
- Author:
Yexin WANG
1
;
Yuanyuan CHENG
;
Jicheng DONG
;
Guoping SUN
;
Ying LU
;
Xiaoling LIANG
Author Information
1. 266000,青岛市精神卫生中心药剂科
- Publication Type:Journal Article
- Keywords:
Antipsychotic agents;
Aripirazole;
Extrapyramidal symptoms
- From:
Adverse Drug Reactions Journal
2018;20(3):235-236
- CountryChina
- Language:Chinese
-
Abstract:
A 56-year-old male patient with undifferentiated type of schizophrenia received one disintegrating tablet of aripiprazole 10 mg orally once daily and the dose of the drug was increased to 30 mg once daily on day 21. Thereafter,the patient′s mental symptoms improved markedly. After receiving aripiprazole for 4 months,the patient developed difficulty in walking. Extrapyramidal symptoms (EPS) induced by aripiprazole was considered. The drug dose was reduced to 25 mg once daily,but the symptoms did not improve,subsequently,hypermyotonia,dysphagia,salivation,mask face,and urinary incontinence appeared. Although the dose of aripirazole was reduced to 5 mg once daily,it did not help to control EPS. Aripirazole was stopped,and 3 days later,the patient′s EPS became aggravated. Intravenous infusions of 0.9% sodium chloride injection 500 ml,Ⅳ vitamin C 2 g,Ⅳ vitamin B6 0.5 g as well as dextrose and sodium chloride injection 500 ml once daily were given to promote drug excretion. The next day,EPS relieved and on day 5,basically faded.
