Anaphylactic shock due to doxapram hydrochloride injection
10.3760/cma.j.issn.1008-5734.2018.03.018
- VernacularTitle:盐酸多沙普仑注射液致过敏性休克
- Author:
Chengjia DAI
1
;
Hongna LI
;
Xiaofeng LIN
;
Yan LIN
Author Information
1. 解放军第一七五医院/厦门大学附属东南医院药学科, 福建漳州,363000
- Publication Type:Journal Article
- Keywords:
Doxapram;
Anaphylaxis;
Shock
- From:
Adverse Drug Reactions Journal
2018;20(3):237-238
- CountryChina
- Language:Chinese
-
Abstract:
A 40-year-old female patient was diagnosed as having left breast cancinoma and underwent modified radical mastectomy. The patient′s surgical procedure was uneventful and her vital signs were stable. After the operation,doxapram hydrochloride 100 mg injection was given by intravenous injection (about 1 minute of completing the injection)to accelerate the patient recovering from the anesthesia. The patient developed shock about 5 minutes after the injection. Her blood pressure fluctuated between 60/46 and 74/54 mmHg,blood oxygen saturation fluctuated between 58% and 74%,and wet rales were audible over both lungs. The patient immediately received oxygen inhalation via a facemask and intravenous injection of adrenaline 40 μg,furosemide 40 mg,and dexamethasone 10 mg. In addition,dopamine 80 mg dissolved in 20 ml of 0.9% sodium chloride injection was administered intravenously via an infusion pump at a rate of 8 ml/h. Twenty minutes later,the patient′s moist rales in both lungs were significantly reduced,her blood pressure was 86/52 mmHg,and oxygen saturation fluctuated between 0.84 and 0.91. On postoperative day 2,the patient had blood pressure 110/70 mmHg,oxygen saturation 0.98,and heart rate 70-80 beats/min. Auscultation revealed the patient had coarse breath sounds in both lungs and slight moist rales were heard in her right lower lung. On postoperative day 5,the patient′s condition was stable and her wound healed well and then she was discharged.
