L-carnitine injection induced epilepsy
10.3760/cma.j.issn.1008-5734.2018.03.019
- VernacularTitle:左卡尼汀注射液诱发癫痫
- Author:
Shubo WANG
1
;
Yong LI
;
Zhilei GUO
Author Information
1. 454002,河南省焦作市人民医院临床药学室
- Publication Type:Journal Article
- Keywords:
Carnitine;
Epilepsy;
Chemically-induced disorders
- From:
Adverse Drug Reactions Journal
2018;20(3):239-240
- CountryChina
- Language:Chinese
-
Abstract:
A 56-year-old female patient was hospitalized because of suffering from chest discomfort for 2 days,and combined with hypertension and diabetes. She received oral valsartan capsules,metoprolol succinate sustained-release tablets,rosuvastatin calcium tablets,aspirin enteric-coated tablets,isosorbide dinitrate tablets,acarbose,and IV infusion of pantoprazole 80 mg+0.9% sodium chloride injection 100 ml and L-carnitine injection 4.0 g +0.9% sodium chloride injection 250 ml once daily. On the third day, about 2 hours after completion of pantoprazole and L-carnitine infusion, the patient presented with unresponsiveness to verbal stimuli,sudden loss of consciousness,limbs convulsion,eyes staring,trismus, and pink frothy sputum. Immediate ECG monitoring,open airway,sucking,oxygen therapy,intramuscular injection of 10 mg diazepam injection,rapid intravenous infusion of glycerol fructose sodium chloride injection 250 ml and 20% mannitol injection 125 ml were given. About 10 minutes later,the patient′s convulsion stopped but she still could not speak and she returned to normal the next day. Symptomatic epilepsy was considered. The probability of epilepsy induced by primary disease was excluded by brain CT and MRI functional imaging examinations and L-carnitine injection was suspected to be associated with the epilepsy. L-carnitine injection was discontinued and other drugs were continued and epilepsy did not recur.
