Severe diarrhea with abdominal pain caused by rectal administration of carboprost methylate suppositories
10.3760/cma.j.issn.1008-5734.2018.03.015
- VernacularTitle:卡前列甲酯栓直肠给药致严重腹泻伴腹痛
- Author:
Jie SHEN
1
;
Hongying REN
;
Hong QI
;
Fengping TAN
Author Information
1. 313300,浙江省安吉县妇幼保健院药剂科
- Publication Type:Journal Article
- Keywords:
Prostaglandins F;
Diarrhea;
Abdominal pain
- From:
Adverse Drug Reactions Journal
2018;20(3):230-232
- CountryChina
- Language:Chinese
-
Abstract:
A 29-year-old female patient received cervical injection of oxytocin injection 10 U twice daily because of postpartum subinvolution of uterus. On the 4th day of treatment,the patient received a transrectal administration of carboprost methylate suppositories 0. 5 mg due to poor efficacy of oxytocin injection. About 20 minutes after rectal medication,the patient developed diarrhea with watery stools 4 times within 70 minutes. About 2 hours after rectal medication,the patient developed persistent abdominal colic and gradually aggravated. Intramuscular injections of metoclopramide 10 mg and pethidine 100 mg were given. However,her abdominal pain did not improve obviously and abdominal ultrasound examination showed no abnormality. Her diarrhea and abdominal pain were considered to be related to carboprost methylate. Symptomatic supportive treatments with spasmolysis,antidiarrheal,potassium supplementation, fluid replacement were given continuously. Five days later,diarrhea and abdominal pain disappeared.
