Cardiac arrest and prolonged QT interval in a patient with motor neuron disease associated with ciprofloxacin
10.3760/cma.j.issn.1008-5734.2017.05.013
- VernacularTitle:环丙沙星致运动神经元病患者心脏骤停及QT间期延长
- Author:
Wenjuan ZHANG
1
;
Junpei LUO
;
Yueqin HU
Author Information
1. 519100 广东珠海,遵义医学院第五附属(珠海)医院药学部;443003 湖北宜昌市中心人民医院/三峡大学第一临床医学院药学部
- Publication Type:Journal Article
- Keywords:
Ciprofloxacin;
Heart arrest;
Torsades de Pointes
- From:
Adverse Drug Reactions Journal
2017;19(5):378-379
- CountryChina
- Language:Chinese
-
Abstract:
A 70-year-old female patient with motor neuron disease was given an IV infusion of ciprofloxacin 0.4 g once daily because of acute exacerbation of chronic bronchitis. On day 10,she developed hypokalemia(blood potassium 2.7 mmol/L)and potassium supplement was given. On day 11,the patient experienced loss of consciousness and cardiac arrest. The patient was given chest compression instantly and regained consciousness in three minutes. Electrocardiogram showed torsades de pointes ventricular tachycardia. Her QT corrected by heart rate(QTc)was 546 ms and blood potassium was 3.4 mmol/L.Potassium supplement was given again. On day 13,the patient′s QTc was 561 ms and blood potassium was 3.2 mmol/L. Ciprofloxacin induced QT interval prolongation was considered. On day 6 of ciprofloxacin withdrawal,the patient′s QTc was 460 ms and blood potassium was 3.9 mmol/L.
