Interstitial pneumonia induced by chemotherapy with gemcitabine and paclitaxel in a patient with breast cancer
10.3760/cma.j.issn.1008-5734.2017.05.014
- VernacularTitle:吉西他滨联合紫杉醇化疗致乳腺癌患者间质性肺炎
- Author:
Qianxin LIU
1
;
Nan ZHAO
1
;
Qian XIANG
1
;
Zhuo ZHANG
1
;
Yimin CUI
1
Author Information
1. 100034,北京大学第一医院药剂科
- Publication Type:Journal Article
- Keywords:
Paclitaxel;
Lung diseases;
interstitial;
Gemcitabine
- From:
Adverse Drug Reactions Journal
2017;19(5):380-381
- CountryChina
- Language:Chinese
-
Abstract:
A 49-year-old female patient with breast cancer received IV infusion of gemcitabine(1.6 g) and paclitaxel(120 mg)at the day 1,8,and 15(the treatment course was 21 d). The routine blood test showed WBC 0.9×109/L,PLT 65×109/L,and neutrophil count 0.3×109/L. The chemotherapy regimen was changed to be given at day 1 and 8 of the treatment cycle and the treatment at day 15 was cancelled. At the 3rd week of the 2nd treatment cycle(the 35th day from treatment start),the patient developed cough and expectoration. Chest X-ray showed a small amount of bilateral pleural effusion and bilateral lung interstitial disease. It was considered that the chemotherapeutic drugs induced the interstitial pneumonia. Treatments with oxygen inhalation,eliminating phlegm and anti-inflammation were given and 13 days later, her cough and expectoration were improved. Because of granulocytic deficiency induced by chemotherapeutic drugs,the chemotherapy was suspended for 10 days and the dose of paclitaxel was changed to 90 mg. At later follow-up,the patient′s condition aggravated,but interstitial pneumonia did not recur.
