Regulatory mechanisms underlying the hair follicle cycling
- VernacularTitle:毛囊生长周期调控的机制研究进展
- Author:
Yuhong CHEN
1
;
Zhongfa LYU
1
Author Information
- Publication Type:Journal Article
- Keywords: Hair follicle; Alopecia; Hair follicle cycle; Signaling pathway; Fibroblast growth factors
- From: Chinese Journal of Dermatology 2025;58(7):686-690
- CountryChina
- Language:Chinese
- Abstract: Hair follicles are skin appendages with a complex structure and periodical self-renewal ability. The hair follicle cycle includes the anagen phase, catagen phase and telogen phase, and its orderly renewal is important to maintain hair growth. It is currently believed that Wnt, bone morphogenetic protein, and Notch signaling pathways are involved in regulating the hair follicle cycle. As research progresses, various regulatory mechanisms based on these signaling pathways have been gradually revealed, such as growth factors, non-coding RNAs, immune responses, etc. This review elaborates on the above molecular mechanisms and regulatory modalities, aiming to promote better understandingn of regulatory mechanisms underlying the hair follicle cycle and provide a theoretical reference for expanding treatment options for hair loss.
