Analysis of the desogestrel and ethinylestradiol contraceptive tablets lead to adverse events venous thrombosis
10.3760/cma.j.issn.1008-5734.2017.05.004
- VernacularTitle:去氧孕烯炔雌醇片致颅内静脉窦血栓形成病例分析
- Author:
Yanqi CHU
1
;
Chen LIU
;
Jiaqi JIANG
;
Tong PEI
;
Zhizhou WANG
;
Suying YAN
Author Information
1. 首都医科大学宣武医院药剂科, 北京,100053
- Publication Type:Journal Article
- Keywords:
Desogestrel;
Ethinyl estradiol;
Sinus thrombosis;
intracranial
- From:
Adverse Drug Reactions Journal
2017;19(5):335-339
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical characteristics of desogestrel and ethinylestradiol contraceptive tablets induced cerebral venous sinus thrombosis(CVST). Methods Five cases with desogestrel and ethinylestradiol contraceptive tablets induced CVST,including 4 cases from Xuanwu Hospital of Capital Medical University and 1 case from domestic literature report,were collected and analyzed. Results The age of the 5 patients was 19-49 years old,and the average age was(37 ± 12)years. One case was overweight. Causes for using drugs were respectively functional uterine bleeding(3 cases),menstrual disorder(1 case)and contraception(1 case),dosage was 1 tablet once daily(take 21 d,stop 7 d,and start the next cycle). One case had overdose before onset(8 tablets). The duration of the drug use was 27 d to 5 years(27 d,50 d and 2,3,5 years). The patients all developed headache(3 cases had severe head pain),consciousness disorder(4 cases),nausea and vomiting(3 cases),and secondary epilepsy (1 case). The results of 5 cases of Naranjo score≥ 7,namely,the correlation between desogestrel and ethinylestradiol tablets with CVST was highly likely. Of four patients admitted to Xuanwu Hospital of Capital Medical University length of stay for 10-40 d,after the intracranial venous sinus thrombectomy,embolectomy and anticoagulant therapy,1 case fully recovered,1 case had left limbs dyskinesia,1 case had legacy dysarthria,and 1 case shifted from coma to lethargy(the patient could open eyes autologously). The case from domestic literature was hospitalized for 30 d,and recovered after anticoagulation treatment. Conclusions The initial symptoms of CVST were non-specific due to the use of desogestrel and ethinylestradiol contraceptive tablets. The patients who had headache after taking the drugs should be considered about CVST and should be screened for the diagnosis as soon as possible. It is better to stop the medicine in time and receive treatment for the adverse effects.
