Advances in metal-organic frameworks for periodontal therapy: from antibacterial applications to tissue regeneration
10.3760/cma.j.cn112144-20250411-00136
- VernacularTitle:金属有机框架材料在牙周治疗中的研究进展：从抗菌到组织再生
- Author:
Jinlong HU
1
;
Dong SHI
1
Author Information
1. 北京大学口腔医学院·口腔医院牙周科 国家口腔医学中心 国家口腔疾病临床医学研究中心 口腔生物材料和数字诊疗装备国家工程研究中心 口腔数字医学北京市重点实验室，北京100081
- Publication Type:Journal Article
- Keywords:
Periodontics;
Periodontal disease;
Metal-organic frameworks;
Antibacterial therapy;
Guided tissue regeneration, periodontal;
Drug delivery;
Nano-medicine
- From:
Chinese Journal of Stomatology
2025;60(12):1417-1422
- CountryChina
- Language:Chinese
-
Abstract:
Periodontal disease is a chronic infectious condition mediated by dental plaque biofilms, characterized by the destruction of soft and hard tissues. Metal-organic frameworks (MOFs), a class of porous materials formed through the self-assembly of metal ions and organic ligands via coordination bonds, exhibit high specific surface areas, tunable pore structures, and multifunctionality. In recent years, MOFs have gained significant attentions in biomedical applications and show potential for periodontal therapy. This article reviews the latest research advances in MOFs for antibacterial therapy, drug delivery, and tissue regeneration, systematically analyzes their mechanisms, application potential, and translational challenges, and furtherly discusses future directions in the era of precision medicine.
