Olanzapine induced delayed-onset rhabdomyolysis
10.3760/cma.j.issn.1008-5734.2017.05.020
- VernacularTitle:奥氮平致迟发性横纹肌溶解症
- Author:
Peishan PANG
1
Author Information
1. 528000广东省佛山市第一人民医院药学部
- Publication Type:Journal Article
- Keywords:
Rhabdomyolysis;
Olanzapine
- From:
Adverse Drug Reactions Journal
2017;19(5):390-392
- CountryChina
- Language:Chinese
-
Abstract:
A 93-year-old patient with Parkinson′s disease and Alzheimer disease received oral levodopa and benserazide hydrochlo-ride 375 mg/d,benzhexol hydrochloride 2 mg/d,donepezil hydro-chloride 5 mg/d,olanzapine 2.5-5.0 mg/d. The patient occasionally felt lower extremities weakness during the medication period. After having olanzapine two and a half years,laboratory examination showed the following levels:lactate dehydrogenase 351 U/L,creatine kinase 1 425 U/L,serum creatine 259 μmol/L. Rhabdomyolysis induced by olanzapine could not be excluded. Olanzapine was stopped. The treatments with an IV infusion of vitamin B650 mg dissolved in 0.9% sodium chloride injection 500 ml once daily and oral sodium bicarbonate 0.5 g thrice daily were given. On day 8,the patient′s lactate dehydrogenase level was 326 U/L,creatine kinase level was 355 U/L,serum creatine level was 63 μmol/L.
