Anaphylactic shock caused by compound ossotide injection
10.3760/cma.j.issn.1008-5734.2017.06.015
- VernacularTitle:注射用复方骨肽致过敏性休克
- Author:
Wenlin SHU
1
;
Zhijian SU
1
Author Information
1. 361009,厦门市中医院药学部
- Publication Type:Journal Article
- Keywords:
Compound ossotide injection;
Anaphylactic shock
- From:
Adverse Drug Reactions Journal
2017;19(6):467-469
- CountryChina
- Language:Chinese
-
Abstract:
A 62-year-old female patient with left knee osteoarthritis was treated with an IV infusion of compound ossotide injection 90 mg dissolving in 0. 9％ sodium chloride injection 250 ml once a day. About 5 minutes after IV infusion on the first day,the patient complained of chest tightness,dyspnea,cold sweat,upper eyelid edema,cyanosis,and vomiting of pale yellow stomach contents. Her blood pressure was 101 / 72 mmHg,heart rate was 103 beats per minute,breathing rate was 25 times per minute. Compound ossotide injection was discontinued immediately. She was given an intravenous injection of dexamethasone 5 mg and an intramuscular injection of adrenaline 1 mg. About 20 minutes later,her blood pressure decreased to 39 / 24 mmHg,pulse rate was 59 beats per minute,breathing rate was 24 times per minute. She developed urinary and fecal incontinence and drowsiness. The patient was diagnosed as anaphylactic shock caused by compound ossotide injection. She was given an intramuscular injection of adrenaline 1 mg again, an IV infusion of dopamine 160 mg,and symptomatic treatment. About 40 minutes later,her heart rate was 70 beats per minute,blood pressure was 95 / 56 mmHg,breathing rate was 12 times per minute. The patient sequentially received an IV infusion of methylprednisolone 40 mg and an intravenous injection of dopamine 10 mg. About 20 minutes later,the patient regained consciousness. Methylepinephrine 10 mg and dopamine 180 mg were pumped with gradually reduced speed. Twelve hours later,the patient′s symptoms disappeared. Her body temperature was 36. 4 ℃,heart rate was 54 beats per minute,breathing rate was 19 times per minute,and blood pressure was 94 / 57 mmHg.
