Ataxia and myodystony due to long-term and high-dose use of compound phenytoin sodium, ephedrin hydrochloride and theophylline tablets
10.3760/cma.j.issn.1008-5734.2017.06.016
- VernacularTitle:长期大剂量服用复方妥英麻黄茶碱片致共济失调和肌张力障碍
- Author:
Yang SUN
1
;
Dongqing PANG
1
;
Linlin LIU
1
;
Fang LIU
1
Author Information
1. 清华大学第一附属医院神经内科,北京,100016
- Publication Type:Journal Article
- Keywords:
Phenytoin;
Ephedrine;
Theophylline;
Ataxia;
Myodystony
- From:
Adverse Drug Reactions Journal
2017;19(6):469-470
- CountryChina
- Language:Chinese
-
Abstract:
A 79-year-old female patient with chronic asthmatoid pulmonary disease received compound phenytoin sodium,ephedrin hydrochloride and theophylline tablets 2 tablets twice daily by mouth. The patient developed discontinuous cephalic and facial involuntary movements after 2 months of medication and discontinuous dizziness with weakness of the lower limbs and gait instability after 9 months of medication. After 1 year of medication,the patient changed 2 to 5 tablets twice daily by herself due to the poor curative effect. Two years after high-dose of treatment,the patient developed aggravated involuntary movements and dizziness,body backward and was unable to stand and walk. Ataxia and myodystony due to long-term and high-dose use of compound phenytoin sodium,ephedrin hydrochloride and theophylline tablets was considered. The drug was stopped,an IV infusion of 0. 9％ sodium chloride injection 500 ml once daily and an intramuscular injection of adenosine cobalamin 1. 5 mg once daily were given. Three days later,the patient′s cephalic and facial involuntary movements disappeared and dizziness markedly alleviated. Five days later,the patient could walk with other person′s help. Eight days later,the patient could walk alone.
