Analysis on risk and related factors of acute renal injury in patients with compound diclofenac sodium injection treatment after surgeries
10.3760/cma.j.issn.1008-5734.2017.06.005
- VernacularTitle:术后镇痛应用复方双氯芬酸钠注射液患者发生急性肾损伤风险及相关因素分析
- Author:
Yan ZHU
1
;
Ping XU
1
;
Qing WANG
1
;
Jianquan LUO
1
;
Yiwen XIAO
1
;
Yangang ZHOU
1
;
Yiyi LI
1
Author Information
1. 中南大学湘雅二医院药学部/临床药学研究所,长沙,410011
- Publication Type:Journal Article
- Keywords:
Meclofenamic acid;
Acetaminophen;
Acute kidney injury
- From:
Adverse Drug Reactions Journal
2017;19(6):420-424
- CountryChina
- Language:Chinese
-
Abstract:
Objective To understand the risk of acute renal injury (AKI)in patients using compound diclofenac sodium injection after surgeries and analyze the influencing factors. Methods Data of patients who had normal renal function before receiving compound diclofenac sodium injection treatment after surgeries in 2015 in the Second Xiangya Hospital of Central South University were collected and studied retrospectively (unmatched case-control study). The patients with AKI after treatment were included in the case group and the patients without AKI were included in the control group. The general condition, postoperative medication,and renal function before and after medication in the 2 groups were compared. The risk and related factors of AKI using compound diclofenac sodium injection were analyzed. Results A total of 821 patients were enrolled into this study,including 63 cases in the case group [43 males and 20 females,average age(51 ± 13)years]and 758 cases in the control group [425 males and 33 females, average age(50 ±14)years]. The proportion of patients with hypertension and liver cirrhosis in the case group was higher than that in the control group [25. 4％ (16/ 63)vs. 13. 1％ (99/ 758),P =0. 009;9. 5％(6 / 63) vs. 2. 8％ (21 / 758),P = 0. 013],the proportion of patients with general surgeries in the case group was higher than that in the control group [42. 9％(27 / 63)vs. 26. 9％ (204 / 758),P = 0. 007],the proportion of patients with neurosurgery in the case group was lower than that in the control group [15. 9％(10 / 63)vs. 33. 5％ (254 / 758),P = 0. 004],the proportion of patients using compound sodium diclofenac injection within 24 h after operation in the case group was higher than that in the control group [20. 6％(13 / 63)vs.10. 7％(81 / 758),P = 0. 017]. The results of binary logistic regression analysis showed that the risk of AKI in patients with hypertension was significantly higher than the other patients with other diseases (OR =2. 847,95％ CI:1. 498-5. 410,P = 0. 001);the risk of AKI in patients with compound diclofenac sodium injection treatment within 24 h after operation was significantly higher than that in patients with compound diclofenac sodium injection treatment 24 h after the surgery(OR =1. 956,95％ CI:1. 154-3. 315,P =0. 013). Conclusion The patients with compound diclofenac sodium injection treatment after surgeries could develop AKI,the combination of hypertension and the use of the drug within 24 hours postoperatively could significantly increase the risk of AKI.
