Research progress in Runt-related transcription factor 2 regulation of bone remodeling and tooth eruption
10.3760/cma.j.cn112144-20250613-00220
- VernacularTitle:Runt相关转录因子2调控骨改建和牙齿萌出过程的研究进展
- Author:
Yang LIU
1
;
Dandan LIU
1
;
Xinyi SUN
1
;
Jinying DU
1
;
Shuguo ZHENG
1
Author Information
1. 北京大学口腔医学院·口腔医院口腔预防科 国家口腔医学中心 国家口腔疾病临床医学研究中心 口腔生物材料和数字诊疗装备国家工程研究中心 口腔数字医学北京市重点实验室 国家卫生健康委口腔数字医学重点实验室 国家药品监督管理局口腔材料重点实验室，北京 100081
- Publication Type:Journal Article
- Keywords:
Tooth eruption;
Runt-related transcription factor 2;
Dental follicle cells;
Osteoblast differentiation;
Osteoclast differentiation
- From:
Chinese Journal of Stomatology
2025;60(11):1300-1308
- CountryChina
- Language:Chinese
-
Abstract:
Cleidocranial dysplasia, a rare genetic disorder primarily caused by Runt-related transcription factor 2 (RUNX2) heterozygous mutation, serves as a representative model for investigating regulatory mechanisms of RUNX2 in bone remodeling and tooth eruption. As a master transcription factor governing mineralized tissue development, RUNX2 orchestrates bone remodeling and tooth eruption through diverse regulatory networks. It drives alveolar bone formation via transcriptional activation, integration of multiple signaling cascades, and epigenetic modifications, thereby generating the biomechanical force for tooth eruption. Concurrently, RUNX2 promotes osteoblastic secretion of osteoclastogenic factors and directly regulates osteoclast precursor differentiation, facilitating bone resorption at the coronal aspect of dental follicles to estavlish the eruption pathway. Furthermore, RUNX2 modulates eruption progression by participating in stress-induced biological signal transduction within dental follicle cells (DFCs), remodeling the DFCs microenvironment, and regulating DFCs senescence. RUNX2 also influences root development via the NOTUM-Wnt axis, providing auxiliary biomechanical conditions conducive to eruption. This review systematically delineates the pivotal role of RUNX2 in coordinating bone remodeling and tooth eruption. Future studies should leverage organoid models and multi-omics technologies to further elucidate the spatiotemporal regulatory networks of RUNX2, potentially advancing precision diagnostics and therapeutics for rare skeletal-dental developmental disorders.
