Anaphylactic shock and erythra induced by pemetrexed disodium injection
10.3760/cma.j.issn.1008-5734.2017.06.014
- VernacularTitle:注射用培美曲塞二钠致过敏性休克及皮疹
- Author:
Xiaoying JI
1
;
Xuliang JIN
1
Author Information
1. 322000,浙江省义乌市中心医院药剂科
- Publication Type:Journal Article
- Keywords:
Pemetrexed;
Anaphylaxis;
Drug eruptions
- From:
Adverse Drug Reactions Journal
2017;19(6):466-467
- CountryChina
- Language:Chinese
-
Abstract:
A 68-year-old male patient with lung cancer received the treatment of combination of pemetrexed disodium and bevacizumab. About 20 minutes after finishing the IV infusion of pemetrexed disodium injection,the patient suddenly developed suppression in the chest,dyspnea,hyperhidrosis,pale, and cyanosis of lips. His heart rate was 98 beats/ min,breathing rate was 24 / min,and blood pressure was 70 / 40 mmHg. He was diagnosed as anaphylactic shock due to pemetrexed disodium. The patient was given nasal catheter oxygen inhalation and ECG monitoring,intravenous injection of adrenalin (1 mg)and dexamethasone (20 mg),immediately. Thirty minutes later,his symptoms were relieved. About 2 hours after the end of IV infusion of pemetrexed disodium,skin rashes occurred on the patient′s chest. He received intramuscular injection of phenergan 12. 5 mg,immediately. Twenty-six minutes later,the rashes disappeared. About 20 minutes after the subsiding of the rashes,he received IV infusion of bevacizumab. The patient did not develop any symptoms.
