Research progress in the relationship between periodontitis and anxiety disorders/depression disorders
10.3760/cma.j.cn112144-20250217-00046
- VernacularTitle:牙周炎与焦虑障碍及抑郁障碍关系的研究进展
- Author:
Baiqiang REN
1
;
Dandan XIANG
1
;
Yuxiang FEI
1
;
Yuqian GUO
1
;
Faming CHEN
1
;
Xuan LI
1
Author Information
1. 空军军医大学口腔医院牙周病科 口颌系统重建与再生全国重点实验室 国家口腔疾病临床医学研究中心 陕西省口腔疾病国际联合研究中心，西安 710032
- Publication Type:Journal Article
- Keywords:
Periodontitis;
Anxiety disorders;
Depression disorders;
Oral-gut-brain axis;
Lipopolysaccharide;
Hypothalamic-pituitary-adrenal axis
- From:
Chinese Journal of Stomatology
2025;60(9):1071-1076
- CountryChina
- Language:Chinese
-
Abstract:
Periodontitis, a common chronic inflammatory disease, progressively damages the supporting tissues of teeth, ultimately resulting in tooth loss. The rising incidence of periodontitis in adults has prompted researchers to observe a frequent co-occurrence of mental health disorders (such as anxiety disorders, depression disorders) in patients undergoing periodontitis onset and treatment. The existence of severe periodontitis can even aggravate the mental and psychological disorders of patients. Furthermore, the long-term fast-paced, high-pressure modern life is easy to cause a series of psychological problems, in turn affecting the occurrence and development of periodontitis. At present, researchers have reported the correlation between periodontitis and anxiety disorders/depression disorders. However, due to the lack of systematic understanding, most of them are clinical investigations or epidemiological statistics without deep mechanism studies. In view of the above problems, this article elucidates the bidirectional relationship between periodontitis and depression/anxiety disorders in recent years by examining recent epidemiological findings, exploring potential bidirectional pathogenic mechanisms, and discussing current treatment strategies. Ultimately, this review seeks to provide new perspectives for improving both oral and mental health outcomes in patients affected by periodontitis and anxiety/depression disorders.
