Advances in animal models and multi-omics technologies for cleft palate research
10.3760/cma.j.cn112144-20250519-00185
- VernacularTitle:腭裂动物模型与多组学分析技术进展
- Author:
Jialin SUN
1
;
Bing SHI
1
;
Zhonglin JIA
1
Author Information
1. 四川大学华西口腔医院唇腭裂外科 口腔疾病防治全国重点实验室 国家口腔医学中心 国家口腔疾病临床医学研究中心，成都 610041
- Publication Type:Journal Article
- Keywords:
Cleft palate;
Animal model;
Animal model construction;
Multi-omics analysis techniques
- From:
Chinese Journal of Stomatology
2025;60(9):1049-1059
- CountryChina
- Language:Chinese
-
Abstract:
Non-syndromic cleft palate only is one of the most common congenital craniofacial malformations, arising from complex interactions between genetic and environmental factors. In recent years, animal models have been extensively utilized in cleft palate research, especially in conjunction with multi-omics technologies such as single-cell RNA sequencing, transcriptomics, proteomics, and epigenomics. These approaches have revealed multidimensional molecular mechanisms underlying cleft palate formation. Animal models provide valuable data for investigating gene regulation and intercellular communication during palatogenesis, offering theoretical foundations for the development of novel early diagnostic tools and therapeutic strategies. This review provides a comprehensive overview of the application of animal models in cleft palate research, with a particular focus on their integration with multi-omics techniques. We discuss how these technologies contribute to uncovering the pathogenic mechanisms of cleft palate and advancing early diagnosis and intervention approaches. Furthermore, we explore the challenges and prospects involved in translating these research findings into clinical applications.
