The clinical value ofmannan binding lectin associated serine protease 2, galectin-3, and midkine in differential diagnosis of thyroid nodules
10.3760/cma.j.cn115455-20241008-00842
- VernacularTitle:甘露聚糖结合凝集素丝氨酸蛋白酶2、半乳糖凝集素-3及中期因子鉴别诊断甲状腺结节的临床价值
- Author:
Xiao HUANG
1
;
Qian ZHU
;
Yating CHEN
;
Peng LI
;
Yan LIU
Author Information
1. 南充市中医医院检验科，南充 637000
- Publication Type:Journal Article
- Keywords:
Thyroid diseases;
Mannan binding lectin serine protease 2;
Galectin-3;
Midkine;
Diagnosis
- From:
Chinese Journal of Postgraduates of Medicine
2025;48(10):953-956
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the clinical value of mannan binding lectin associated serine protease 2 (MASP-2), galectin-3, and midkine in the differential diagnosis of thyroid nodules.Methods:From March 2021 to March 2022, 75 patients (study group) with thyroid nodules admitted to the Nanchong Hospital of Traditional Chinese Medicine and 50 volunteers(control group) who underwent health examinations during the same period were retrospectively selected. The levels of MASP-2, galectin-3 and midkine were compared between the two groups, and the levels of MASP-2, galectin-3 and midkine in benign and malignant thyroid nodules in the study group were compared. The predictive value of MASP-2, galectin-3, midkine and combined tests for malignant thyroid nodules diagnosis was analyzed by receiver operating characteristic (ROC) curve.Results:The levels of MASP-2, galectin-3, midkine in the study group were higher than those in the control group: (433.92 ± 35.01) mg/L vs. (215.12 ± 22.60) mg/L, (26.73 ± 3.12) μg/L vs. (20.51 ± 2.10) μg/L, (258.96 ± 27.03) ng/L vs. (122.47 ± 15.72) ng/L, there were statistical differences ( P<0.05). The levels of MASP-2, galectin-3, midkine in the patients with malignant nodules were higher than those in the patients with benign thyroid nodules: (541.27 ± 57.35) mg/L vs. (400.02 ± 30.17) mg/L, (41.68 ± 5.23) μg/L vs. (22.01 ± 2.89) μg/L, (318.97 ± 40.23) ng/L vs. (240.01 ± 25.01) ng/L, there were statistical differences ( P<0.05). ROC curve analysis showed that the area under the curve (AUC) of MASP-2, galectin-3 and midkine in the diagnosis of malignant thyroid nodules was the highest (0.819), which was higher than that of any single index. Conclusions:The serum levels of MASP-2, galectin-3 and midkine in patients with malignant nodules were higher than those in patients with benign nodules, and the combined value of MASP-2, galectin-3 and midkine is higher in predicting malignant thyroid nodules.
