Clinical effects of vitamin D combined with conventional anti-infective therapy and formula feeding in the treatment of preterm infants with infectious diseases
10.3760/cma.j.cn115455-20240626-00539
- VernacularTitle:维生素D联合常规抗感染方案及配方奶喂养治疗伴感染性疾病早产儿的临床效果
- Author:
Yue SUN
1
;
Rui ZHANG
;
Na LI
Author Information
1. 河北省沧州中西医结合医院中药制剂科，沧州 061000
- Publication Type:Journal Article
- Keywords:
Infant, premature, diseases;
Inflammation;
Vitamin D;
Immunoglobulins
- From:
Chinese Journal of Postgraduates of Medicine
2025;48(10):912-916
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinical effectiveness of vitamin D combined with conventional anti-infective therapy and formula feeding in the treatment of preterm infants with infectious diseases.Methods:A total of 150 premature infants with infectious diseases treated in Hebei Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine from January to December 2022 were prospectively selected as the study objects, and divided into the control group and the study group according to the admission sequence number, with 75 cases in each group. The control group was treated with routine anti-infection regimen and formula feeding, and the study group was combined with early vitamin D supplementation on the basis of the control group. Both groups were treated continuously for 4 weeks. Serum prealbumin (pre-Alb), 25-hydroxyvitamin D[25-(OH)D], immune indexes and inflammatory response indexes were compared between the two groups before and after treatment, and neonatal complications and adverse reactions were compared between the two groups.Results:After treatment, the levels of serum 25-(OH)D and pre-Alb in the study group were higher than those in the control group: (37.58 ± 4.02) nmol/L vs. (27.20 ± 3.75) nmol/L, (141.27 ± 16.79) mg/L vs. (132.83 ± 16.36) mg/L, there were statistical differences ( P<0.05). After treatment, the levels of serum complement C3, C4, immunoglobulin (Ig) M and IgG in the study group were higher than those in the control group : (0.92 ± 0.15) g/L vs. (0.77 ± 0.19) g/L, (0.18 ± 0.05) g/L vs. (0.15 ± 0.04) g/L, (0.24 ± 0.04) g/L vs. (0.22 ± 0.05) g/L, (8.07 ± 1.05) g/L vs. (7.68 ± 1.13) g/L, there were statistical differences ( P<0.05). After treatment, the serum levels of interleukin-2 (IL) in the study group was higher than that in the control group, while the levels of IL-4, amyloid A (SAA), soluble human tumor necrosis factor receptor 1 (sTNFR-1) and Toll-like receptor 4 (TLR4) in the study group were lower than those in the control group: (4.61 ± 1.14) pg/L vs. (3.81 ± 0.91) pg/L, (20.53 ± 2.61) pg/L vs. (23.97 ± 3.12) pg/L, (5.56 ± 1.78) mg/L vs. (7.24 ± 1.93) mg/L, (4.16 ± 1.27) mg/L vs. (6.08 ± 1.54) mg/L, (75.21 ± 7.39) mg/L vs. (81.42 ± 8.17) mg/L, there were statistical differences ( P<0.05). The incidence rates of neonatal pneumonia, necrotizing enterocolitis (NEC) and metabolic bone disease in the study group were lower than those in the control group: 1.33%(1/75) vs. 10.67%(8/75), 1.33%(1/75) vs. 10.67%(8/75), 0 vs. 9.33%(7/75), there were statistical differences ( P<0.05). Conclusions:Vitamin D supplementation can effectively maintain the nutritional status of premature infants with infectious diseases and improve the immune system function, regulate inflammation and reduce complications.
