Progress in the application of therapeutic hypothermia for neonatal hypoxic-ischemic encephalopathy
10.3760/cma.j.issn.1673-4912.2025.06.015
- VernacularTitle:亚低温治疗在新生儿缺氧缺血性脑病的应用进展
- Author:
Meng WEI
1
;
Xinhua ZHANG
Author Information
1. 山西医科大学儿科医学系，太原 030000
- Publication Type:Journal Article
- Keywords:
Therapeutic hypothermia;
Newborn;
Hypoxic-ischemic encephalopathy;
Combination therapy
- From:
Chinese Pediatric Emergency Medicine
2025;32(6):476-480
- CountryChina
- Language:Chinese
-
Abstract:
Neonatal hypoxic-ischemic encephalopathy (HIE) refers to hypoxic-ischemic brain damage caused by perinatal asphyxia.Its manifestations are diverse，which can cause a series of neurological dysfunction，and it is one of the main causes of neonatal death and disability in China.Therapeutic hypothermia has become a recognized treatment for HIE at present，which can significantly reduce the mortality and disability rate of moderate and severe HIE and improve the outcome of neurological development.This review summarized the implementation strategies of therapeutic hypothermia，including cooling mode，time window，target temperature，duration，rewarming speed，object selection，contraindications，and the progress of combination therapies，in order to optimize the therapeutic hypothermia scheme of HIE.
