Correlation between pulmonary surfactant protein-C gene variation and pediatric pulmonary diseases

VernacularTitle:肺表面活性蛋白C基因变异与儿童肺部疾病相关性研究进展
Author: Wenxin WEI ¹ ; Hua MEI ¹ ; Yanbo ZHANG ¹
Author Information

1. 内蒙古医科大学附属医院新生儿科，呼和浩特　010050
Publication Type:Journal Article
Keywords: Pulmonary surfactant protein-C; Neonatal respiratory distress syndrome; Gene mutation
From: Chinese Pediatric Emergency Medicine 2024;31(12):934-938
CountryChina
Language:Chinese
Abstract: Neonatal respiratory distress syndrome (NRDS) is one of the most common respiratory critical diseases in neonates,especially in very premature infants and very low birth weight infants.The incidence of NRDS is higher in neonatal age.NRDS is not only a major cause of death in preterm infants,but also a major factor leading to the development of bronchopulmonary dysplasia,and its pathogenesis is closely related to the mutation of the gene for pulmonary surfactant protein (SP).SP-C is one of the SPs,which is essential for the formation of pulmonary surfactant,and plays a key role in maintaining the normal function of pulmonary surfactant.SP-C is an extremely important component of pulmonary surfactant.The study of the relationship between gene mutation of SP-and NRDS is helpful for early gene intervention,promoting clinical diagnosis and treatment,and has long-term significance for reducing neonatal mortality.